Pathology Portal

Investigation of hypoglycaemia in the newborn/infants/children

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Hypoglycaemia can become a diagnostic odyssey when found in the newborn and the investigation path can direct to both IMD and non-IMD causes (e.g. endocrine). The samples required need to be taken in a timely fashion and expedited given the time critical nature of some of the disorders. It is important for clinical biochemists to understand why certain investigations are taken and how they inform the differential diagnosis. The file at this link goes through this in step wise fashion.

Reflective exercise

Consider the volume requirements for the variety of tests and the challenges this poses when needed in the neonate given the total blood volume and elevated haematocrit of neonatal samples. If you were posed with the challenge of prioritising tests, how would you go about this if only a limited blood volume could be collected?

Resource details

Contributed by: Pathology Portal
Authored by: Nathan Cantley, Department of Clinical Biochemistry, Southmead Hospital, North Bristol Trust, Chemical Pathology SpR
MetBioNet, Metabolic Biochemistry Network
Licence: More information on licences
First contributed: 16 August 2023
Audience access level: Full user

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