You have to be signed in to use this resource.
Data-driven modelling of intercellular interactions in the tumour microenvironment
Monocyte-derived macrophages help maintain tissue homeostasis and defend the organism against pathogens. In tumours, recent studies have uncovered complex macrophage populations, including tumour-associated macrophages, which support tumorigenesis through cancer hallmarks such as immunosuppression, angiogenesis or matrix remodelling. In the case of chronic lymphocytic leukaemia, these macrophages are known as nurse-like cells and they protect leukemic cells from spontaneous apoptosis contributing to their chemoresistance. We propose an agent-based model of monocyte differentiation into nurse-like cells upon contact with leukemic B cells in vitro. We performed patient-specific model calibrations using cultures of peripheral blood mononuclear cells from patients. Using our model, we were able to reproduce temporal survival dynamics of cancer cells in a patient-specific manner and to identify patient groups related to distinct macrophage phenotypes. Our results show a potentially important role of phagocytosis in the polarization process of nurse-like cells and in promoting cancer cells' enhanced survival
Who is this course for?
This webinar is part ofPerMedCoEwebinar series and is open for researchers in the life sciences, biomedical scientists and anyone interested in immuno-oncology as well asin simulation of intercellular interactions.
The goal of PerMedCoE is to provide an efficient and sustainable entry point to the HPC/Exascale-upgraded methodology to translate omics analyses into actionable models of cellular functions of medical relevance.
Outcomes
By the end of this webinar, you will be able to:
- Describe the challenges of data-driven modelling
- Cite simple models of immuno-oncology dynamics in simplified experimental systems
Resource details
| Contributed by: | Pathology Portal |
| Authored by: |
|
| Licence: | More information on licences |
| First contributed: | 02 July 2023 |
| Audience access level: | Full user |
Share this resource
Report an issue with this resource
You may report a resource, for example, if there is an issue with copyright infringement, breach of personal data, factual inaccuracies, typing errors or safety concerns. The type of issue will determine whether the resource is immediately removed from the platform or if the contributor is asked to make amendments. You can report a resource from the resource information page or by contacting the Learning Hub support team.
You can contact the Learning Hub support team by completing the support form or if you have a general enquiry you can email enquiries@learninghub.nhs.uk.