Curating proteins involved in Antimicrobial Resistance (AMR) in UniProt

UniProt is a comprehensive, expert-led, publicly available database of protein sequence, function, and variation information.

This webinar will give a brief introduction to the UniProt website and then highlight resources which should be of interest to people beginning work on antimicrobial resistance (AMR), including students, early-stage researchers, and clinicians.

AMR constitutes one of the world’s most urgent public health problems.

We have been improving the annotation of various protein classes with a known role in AMR, including beta-lactamases, efflux pumps, ABC transporters, and a group of proteins, essential for the survival of resistant bacteria under therapeutic concentrations of antimicrobials, collectively known as the secondary resistome. Using these as examples, we will introduce some of the UniProt resources.

UniProt annotations are widely disseminated to other databases, including Rhea, EnsemblBacteria, PATRIC (Bacterial & Viral Bioinformatics Resource Center), BioCyc/EcoCyc and KEGG.

Please also take this opportunity to suggest additional curation targets to us, to enable us to better support ongoing AMR research.

Who is this course for?

This webinar is aimed at students, early-stage career computational and wet-lab scientists, and clinicians, with minimal prior knowledge of the proteins involved in antimicrobial resistance. An undergraduate level knowledge of protein biology will be useful.

This webinar is designed as a brief general introduction to UniProt resources and to proteins which play a role in antimicrobial resistance.

Outcomes

By the end of the webinar you will be able to:

• Use the UniProt website to find and gain useful information about proteins which play roles in AMR