Neurogenic Bowel Dysfunction in Children and Adolescents (PDF)

Abstract: Neurogenic/neuropathic bowel dysfunction (NBD) is common in children who are affected
by congenital and acquired neurological disease, and negatively impacts quality of life. In the past,
NBD received less attention than neurogenic bladder, generally being considered only in spina bifida
(the most common cause of pediatric NBD). Many methods of conservative and medical management
of NBD are reported, including relatively recently Transanal Irrigation (TAI). Based on the literature
and personal experience, an expert group (pediatric urologists/surgeons/gastroenterologists with
specific experience in NBD) focused on NBD in children and adolescents. A statement document
was created using a modified Delphi method.The range of causes of pediatric NBD are discussed in
this paper. The various therapeutic approaches are presented to improve clinical management. The
population of children and adolescents with NBD is increasing, due both to the higher survival rate
and better diagnosis. While NBD is relatively predictable in producing either constipation or fecal
incontinence, or both, its various effects on each patient will depend on a wide range of underlying
causes and accompanying comorbidities. For this reason, management of NBD should be tailored
individually with a combined multidisciplinary therapy appropriate for the status of the affected
child and caregivers.

Citation: Mosiello, G.; Safder, S.;Marshall, D.; Rolle, U.; Benninga,M.A. Neurogenic Bowel Dysfunction in Children and Adolescents. J.Clin.Med. 2021, 10, 1669. https://doi.org/10.3390/jcm10081669