Pathology Portal

Neuropathology Nuggets! How can molecular pathology help me with my diagnostic work?

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Welcome to another case in the 'Neuropathology Nuggets' series! 

In this video, I will take a look at a case of a low grade glioma and help you to answer the following points:

- What are some of the features of a low grade glioma on an intraoperative smear?

- What are some of the histological features to look out for to support the diagnosis of a low grade glioma?

- How can immunohistochemistry help me to decide on my tumour type - astrocytoma vs oligodendroglioma?

- What is methylation profiling and how can it help in this case?

I hope you enjoy the case! If you want to read more about methylation profiling, please take a look at the paper (Capper et al (2018) Nature) which has been uploaded to the portal as a resource. 

Resource details

Contributed by: Pathology Portal
Authored by: Matthew Clarke, UCLH, Academic Clinical Lecturer (ACL) - Diagnostic Neuropathology
Licence: © All rights reserved More information on licences
First contributed: 14 September 2021
Audience access level: Full user

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