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Infant high-grade gliomas - histological and molecular characteristics!!
It has been known for some time that infant high-grade gliomas have a better outcome compared to their older counterparts. And we now know why! This paper explores how they have been classified and characterised using methylation profiling, fusion panel / whole genome / exome sequencing and a histological review.
The study shows that they often classify as infantile hemispheric gliomas (IHG) with over 60% of them characterised by an RTK fusion (ALK, NTRK, ROS1 or MET). Interestingly, this is the ONLY mutation found in these cases, which provides a tantalising opportunity to target the driving mutation and treat the tumour! Lots of clinical cases discussed too!
Have a look to find out more!!!
Resource details
| Contributed by: | Pathology Portal |
| Authored by: |
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| Authored on: | 1 April 2020 |
| Licence: | Creative commons: Attribution-NonCommercial 4.0 International More information on licences |
| First contributed: | 24 August 2021 |
| Audience access level: | Full user |
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