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Introduction to cancer genomics and its caveats
Overview: Cancer genomes contain a wide range of somatic variants – DNA differences between tumor cells and normal host cells. In addition, inherited germline variants may predispose to cancer. Researchers use DNA sequencing to discover somatic and germline variants, identify cancer driver mutations and infer clonal tumor architecture. In this lecture we will discuss the challenges of cancer genomics and the computational methods used to analyse cancer genomes.
Learning outcomes
By the end of this session you will be able to:
- Describe methods of analysis for genomics datasets
- Identify caveats for these analysis methods
- Explain the concepts tumour purity, tumour heterogeneity, tumour ploidy and, somatic and germline mutations
Resource details
| Contributed by: | Pathology Portal |
| Authored by: |
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| Licence: | More information on licences |
| First contributed: | 07 July 2024 |
| Audience access level: | General user |
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